CovMT could help researchers to track evolution of SARS-CoV-2 mutations – News-Medical.Net

A SARS-CoV-2 tracker uses publicly available sequencing data to show how the virus is changing and spreading over time. The tracker, called CovMT, was developed at KAUST and is expected to help researchers and policymakers understand the evolution of the virus’s mutations.

This could have implications for vaccine development, patient treatment and the implementation of restrictions.

“As new variants of the SARS-CoV-2 virus emerge, authorities around the world need to know if these, or similar variants, have entered their countries,” says computational biologist, Intikhab Alam, who designed the CovMT system with a team in KAUST’s Computational Bioscience Research Center.

“The World Health Organization is stressing to all countries to ramp up their sequencing efforts. With this increase in sequencing, we expect CovMT will help researchers, the public and policymakers to explore up-to-date country-specific information on sequencing efforts, evolving virus variants and disease severity.”

Each day, publicly available data is downloaded to CovMT from GISAID, an initiative that collates genetic sequences and the related clinical and epidemiological data about the SARS-CoV-2 virus from various parts of the world. The CovMT platform processes this data to detect mutations and mutation fingerprints and define clades.

CovMT then provides interactive graphics to help visualize the results in a user-friendly form.

For example, the tracker shows which SARS-CoV-2 clades are present in which continents. It also shows the countries that are providing SARS-CoV-2 sequencing data and the local and foreign mutational fingerprints of the virus present in each country.

The team devised the concept of “mutational fingerprints” to describe virus